Fax: 301-402-0491.
Review
The new standard of HCV therapy: Retreatment in experienced patients †‡
Article first published online: 6 MAR 2012
DOI: 10.1002/cld.4
Copyright © 2012 the American Association for the Study of Liver Diseases
Issue
2046-2484/asset/cover.gif?v=1&s=4eb4447076d62f74223c3c3775332c119f8c59a5)
Clinical Liver Disease
Special Issue: Hepatitis C Infection - Treatment: Part 1
Volume 1, Issue 1, pages 16–19, February 2012
Additional Information
How to Cite
Gara, N. and Ghany, M. G. (2012), The new standard of HCV therapy: Retreatment in experienced patients . Clinical Liver Disease, 1: 16–19. doi: 10.1002/cld.4
- †
This research was supported by the Intramural Research Programs of the National Institute of Diabetes and Digestive and Kidney Diseases and the National Cancer Institute (National Institutes of Health).
- ‡
Potential conflict of interest: Nothing to report
- §
Fax: 301-402-0491.
Publication History
- Issue published online: 6 MAR 2012
- Article first published online: 6 MAR 2012
References
- 1, , , , , , et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C: effects of dose and duration. Hepatology 1996;24:778–789.
- 2, , , , , , et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001;358:958–965.
- 3, , , , , , et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975–982.
- 4
- 5, , , , , , et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009;461:399–401.
- 6, , , , , , et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009;41:1105–1109.
- 7, , , , , et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 2010;138:1338–1345.
- 8, , , , , , et al. Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C. Gastroenterology 2007;132:103–112.
- 9, , , , , , et al. Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. Gastroenterology 2002;123:1061–1069.
- 10
- 11, , , , , , et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 2009;136:1618–1628.
- 12, , , , , , et al. Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results. Hepatology 2009;49:1838–1846.
- 13, , , , , , et al. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med 2008;359:2429–2441.
- 14, , , , , Colchicine versus peg-interferon alfa 2b long term therapy: results of the 4 year COPILOT trial. J Hepatol 2008;48:S4.
- 15, , , , , , et al. PegIntron maintenance therapy in cirrhotic (METAVIR F4) HCV patients who failed to respond to interferon/ribavirin (IR) therapy: final results of the EPIC3 cirrhosis maintenance trial. J Hepatol 2009;50:S22.
- 16
- 17
- 18
- 19
- 20Food and Drug Administration. Prescribing information for Incivek. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201917lbl.pdf. Accessed January 2012.
- 21
- 22, , , , . An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011; 54:1433–1444.

2046-2484/asset/olbannerleft.gif?v=1&s=7f2a3607d5ffcd2fe8865cbc33a78bcc8ad56034)
2046-2484/asset/olbannerright.gif?v=1&s=729a6df7173779180a9a9e10939a006f346e78ff)