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Pediatric nonalcoholic fatty liver disease: Prevalence, diagnosis, risk factors, and management†
Article first published online: 25 SEP 2012
DOI: 10.1002/cld.75
Copyright © 2012 the American Association for the Study of Liver Diseases
Issue
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Clinical Liver Disease
Special Issue: Non-alcoholic Fatty Liver Disease
Volume 1, Issue 4, pages 124–127, September 2012
Additional Information
How to Cite
Xanthakos, S. A. and Kohli, R. (2012), Pediatric nonalcoholic fatty liver disease: Prevalence, diagnosis, risk factors, and management. Clinical Liver Disease, 1: 124–127. doi: 10.1002/cld.75
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Publication History
- Issue published online: 25 SEP 2012
- Article first published online: 25 SEP 2012
References
- 1, , , , , Prevalence of fatty liver in children and adolescents. Pediatrics 2006; 118: 1388-1393.
- 2, , , , , , et al. Rapid progression of NASH in childhood. J Pediatr Gastroenterol Nutr 2010; 50: 453-456.
- 3, , , Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastroenterol 2002; 97: 2460-2462.Direct Link:
- 4, , , , , The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009; 58: 1538-1544.
- 5, , , , , , et al. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology 2010; 52: 1281-1290.Direct Link:
- 6, , , , , , et al. I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Hepatology 2010; 52: 1274-1280.
- 7, , , , , , et al. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology 2012; 55: 781-789.
- 8, , , , , , et al. Association between metabolic syndrome and liver histology among children with nonalcoholic fatty liver disease. Am J Gastroenterol 2010; 105: 2093-2102.
- 9, , , , , The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease. BMC Med 2009; 7: 21.
- 10, , , , , , et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology 2010; 51: 1961-1971.
- 11, , , , , , et al.; for NASH CRN Research Group. Correlation of vitamin E, uric acid and diet composition with histologic features of pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2012; 54: 90.
- 12Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007; 120(suppl 4): S164-S192.
- 13, , , , , , et al. Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab 2008; 93: 4576-4599.
- 14, , , , , , et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the Espghan Hepatology Committee. J Pediatr Gastroenterol Nutr 2012; 54: 700-713.
- 15, , , , , , et al. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology 2010; 138: 1357-1364.
- 16, , , , , , et al. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology 2009; 50: 1113-1120.
- 17, , , , , , et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology 2008; 48: 442-448.
- 18, , , , , Pediatric MR elastography of hepatic fibrosis: principles, technique and early clinical experience. Pediatr Radiol 2012; 42: 402-409.
- 19, , , , , , et al. A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis. Clin Gastroenterol Hepatol 2011; 9: 150-155.
- 20, , , , , , et al. Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology 2008; 48: 119-128.
- 21
- 22, , , , , , et al. A multidisciplinary clinical program is effective in reducing BMI and ALT in pediatric patients with NAFLD. J Pediatr Gastroenterol Nutr 2010; 51: E68.
- 23
- 24, , , , Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008:CD007176.
- 25
- 26, , , , , , et al. Best practice updates for pediatric/adolescent weight loss surgery. Obesity (Silver Spring) 2009; 17: 901-910.
- 27, , , , , Bariatric surgery for non-alcoholic steatohepatitis in obese patients. Cochrane Database Syst Rev 2010:CD007340.
- 28, , Systematic review and meta-analysis of bariatric surgery for pediatric obesity. Ann Surg 2008; 248: 763-776.

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