Monitoring Editor: Pekka Lappalainen
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity†
Article first published online: 23 AUG 2010
Copyright © 2010 Wiley-Liss, Inc.
Volume 67, Issue 9, pages 545–554, September 2010
How to Cite
Amano, M., Nakayama, M. and Kaibuchi, K. (2010), Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton, 67: 545–554. doi: 10.1002/cm.20472
- Issue published online: 23 AUG 2010
- Article first published online: 23 AUG 2010
- Manuscript Accepted: 13 JUL 2010
- Manuscript Revised: 7 JUL 2010
- Manuscript Received: 24 FEB 2010
Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological analyses have revealed that Rho-kinase is involved in a wide range of diseases such as vasospasm, pulmonary hypertension, nerve injury, and glaucoma, and is therefore considered to be a potential therapeutic target. This review focuses on the structure, function, and modes of activation and action of Rho-kinase. © 2010 Wiley-Liss, Inc.