Monitoring Editor: Peter Baas
Article first published online: 26 APR 2012
Published 2012 Wiley Periodicals, Inc.
Special Issue: Emerging Concepts in Neuronal Cytoskeleton
Volume 69, Issue 7, pages 442–463, July 2012
How to Cite
Garnham, C. P. and Roll-Mecak, A. (2012), The chemical complexity of cellular microtubules: Tubulin post-translational modification enzymes and their roles in tuning microtubule functions. Cytoskeleton, 69: 442–463. doi: 10.1002/cm.21027
This article is a US government work and, as such, is in the public domain in the United States of America.
- Issue published online: 6 JUL 2012
- Article first published online: 26 APR 2012
- Accepted manuscript online: 15 MAR 2012 02:39PM EST
- Manuscript Accepted: 7 MAR 2012
- Manuscript Revised: 28 FEB 2012
- Manuscript Received: 16 NOV 2011
- tubulin modifications;
- post-translational modifications
Cellular microtubules are marked by abundant and evolutionarily conserved post-translational modifications that have the potential to tune their functions. This review focuses on the astonishing chemical complexity introduced in the tubulin heterodimer at the post-translational level and summarizes the recent advances in identifying the enzymes responsible for these modifications and deciphering the consequences of tubulin's chemical diversity on the function of molecular motors and microtubule associated proteins. Published 2012 Wiley Periodicals, Inc.