Communication

Synthesis and Activity of Carbazole Derivatives Against Mycobacterium tuberculosis†

  1. Taylor A. Choi1,2,
  2. Regina Czerwonka1,
  3. Wolfgang Fröhner Dr.1,
  4. Micha P. Krahl1,
  5. Kethiri R. Reddy Dr.1,
  6. Scott G. Franzblau Prof. Dr.2,
  7. Hans-Joachim Knölker Prof. Dr.1

Article first published online: 28 JUN 2006

DOI: 10.1002/cmdc.200600002

Issue

ChemMedChem

ChemMedChem

Volume 1, Issue 8, pages 812–815, August 11, 2006

Additional Information

How to Cite

Choi, Taylor A., Czerwonka, R., Fröhner, W., Krahl, Micha P., Reddy, Kethiri R., Franzblau, Scott G. and Knölker, H.-J. (2006), Synthesis and Activity of Carbazole Derivatives Against Mycobacterium tuberculosis. ChemMedChem, 1: 812–815. doi: 10.1002/cmdc.200600002

Author Information

  1. 1

    Department Chemie, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany, Fax: (+49) 351-463-37030

  2. 2

    Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., MC 964, Chicago, IL 60612-7231, USA, Fax: (+1) 312-355-2693

  1. †

    Transition Metal Complexes for Organic Synthesis, Part 79. Part 78: J. Knöll, H.-J. Knölker, Synlett 2006, 651.

Publication History

  1. Issue published online: 3 AUG 2006
  2. Article first published online: 28 JUN 2006
  3. Manuscript Revised: 25 APR 2006
  4. Manuscript Received: 4 JAN 2006

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Keywords:

  • carbazoles;
  • natural products;
  • structure–activity relationships;
  • tuberculosis
Thumbnail image of graphical abstract

A series of carbazole derivatives was tested for inhibition of Mycobacterium tuberculosis growth and a mammalian cell line. Among several compounds with anti-TB activity, carbazoles A and B showed MIC values of 4.0 μg mL−1 (8 μM) and 2.2 μg mL−1 (9 μM) respectively, against M. tuberculosis and were relatively nontoxic for the mammalian cell line.

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