Communication

Permeability of Phospholipid Vesicles to the Tumor Antigen Epitope gp100280–288

  1. Antonella Cavazza Dr.1,
  2. Mario Marini1,
  3. Giulio C. Spagnoli Dr.2,
  4. Michel Adamina Dr.2,
  5. L. Giorgio Roda Prof.1

Article first published online: 3 AUG 2006

DOI: 10.1002/cmdc.200600019

Issue

ChemMedChem

ChemMedChem

Volume 1, Issue 8, pages 816–820, August 11, 2006

Additional Information

How to Cite

Cavazza, A., Marini, M., Spagnoli, Giulio C., Adamina, M. and Roda, L. Giorgio. (2006), Permeability of Phospholipid Vesicles to the Tumor Antigen Epitope gp100280–288. ChemMedChem, 1: 816–820. doi: 10.1002/cmdc.200600019

Author Information

  1. 1

    Dipartimento di Neuroscienze, Università degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133 Roma,, Italy, Fax: (+39) 6 72596407

  2. 2

    ICFS und Department Forschung, Universität Basel, Hebelstrasse 20, 4031 Basel, Switzerland

Publication History

  1. Issue published online: 3 AUG 2006
  2. Article first published online: 3 AUG 2006
  3. Manuscript Revised: 3 MAY 2006
  4. Manuscript Received: 25 JAN 2006

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Keywords:

  • antigens;
  • antitumor agents;
  • drug delivery;
  • lipid vesicles;
  • peptides
Thumbnail image of graphical abstract

The permeability of phospholipid vesicles to a class I-restricted epitope derived from the melanoma-associated protein, gp100280–288, and its possible effects on epitope degradation by fibroblast-expressed proteolytic enzymes were studied. The results indicate that the majority of the peptide may not be contained within the lipid vesicles when administered for vaccination.

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