Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct-analysis-in-real-time Coupled to Time-of-flight Mass Spectrometry

Authors

  • Facundo M. Fernández Prof. Dr.,

    1. School of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State St. Atlanta, GA 30332, USA, Fax: (+1) 404-385-6447
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  • Robert B. Cody Dr.,

    1. JEOL USA, Inc. 11 Dearborn Road, Peabody, MA 01960, USA
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  • Michael D. Green Dr.,

    1. Division of Parasitic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, 1600 Clifton Road, Mailstop F12, Atlanta, GA 30333, USA
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  • Christina Y. Hampton,

    1. School of Chemistry and Biochemistry, Georgia Institute of Technology, 770 State St. Atlanta, GA 30332, USA, Fax: (+1) 404-385-6447
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  • Rose McGready Dr.,

    1. Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
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  • Sivong Sengaloundeth Dr.,

    1. Food and Drug Department, Ministry of Health, Government of the Lao PDR, Vientiane (Lao PDR)
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  • Nicholas J. White Prof.,

    1. Microbiology Laboratory, Mahosot Hospital, Wellcome Trust–Mahosot Hospital–Oxford Tropical Medicine Research Collaboration, Vientiane (Lao PDR)
    2. Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford University, Oxford, OX3 7LJ, UK
    3. Prof. White is also affiliated with: Wellcome Trust–Mahidol University–Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
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  • Paul N. Newton Dr.

    1. Microbiology Laboratory, Mahosot Hospital, Wellcome Trust–Mahosot Hospital–Oxford Tropical Medicine Research Collaboration, Vientiane (Lao PDR)
    2. Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford University, Oxford, OX3 7LJ, UK
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Abstract

original image

Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown).

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