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Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones

  1. Stefanie Weyler Dr.1,2,3,
  2. Friederike Fülle Dr.1,2,4,
  3. Martina Diekmann Dr.1,2,
  4. Britta Schumacher Dr.1,2,
  5. Sonja Hinz1,2,
  6. Karl-Norbert Klotz Prof. Dr.1,2,
  7. Christa E. Müller Prof. Dr.1,2

Article first published online: 10 JUL 2006

DOI: 10.1002/cmdc.200600066

Issue

ChemMedChem

ChemMedChem

Volume 1, Issue 8, pages 891–902, August 11, 2006

Additional Information

How to Cite

Weyler, S., Fülle, F., Diekmann, M., Schumacher, B., Hinz, S., Klotz, K.-N. and Müller, Christa E. (2006), Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones. ChemMedChem, 1: 891–902. doi: 10.1002/cmdc.200600066

Author Information

  1. 1

    University of Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry Poppelsdorf, Kreuzbergweg 26, 53115 Bonn, Germany

  2. 2

    University of Würzburg, Institute of Pharmacology and Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany, Fax: (+49) 228-73-2567

  3. 3

    present address: Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach, Germany

  4. 4

    present address: Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM), Kurt-Georg-Kiesinger Allee 3, 53175 Bonn, Germany

Publication History

  1. Issue published online: 3 AUG 2006
  2. Article first published online: 10 JUL 2006
  3. Manuscript Received: 14 MAR 2006

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