Communication

In Situ Polymerized Hydrogels for Repairing Scleral Incisions Used in Pars Plana Vitrectomy Procedures†

  1. Michel Wathier Dr.1,
  2. M. Starck Johnson Dr.2,
  3. Michael A. Carnahan Dr.2,
  4. Claxton Baer Dr.2,
  5. Brooks W. McCuen Dr.2,
  6. Terry Kim Dr.2,
  7. Mark W. Grinstaff Prof.1

Article first published online: 31 JUL 2006

DOI: 10.1002/cmdc.200600090

Issue

ChemMedChem

ChemMedChem

Volume 1, Issue 8, pages 821–825, August 11, 2006

Additional Information

How to Cite

Wathier, M., Johnson, M. Starck., Carnahan, Michael A., Baer, C., McCuen, Brooks W., Kim, T. and Grinstaff, Mark W. (2006), In Situ Polymerized Hydrogels for Repairing Scleral Incisions Used in Pars Plana Vitrectomy Procedures. ChemMedChem, 1: 821–825. doi: 10.1002/cmdc.200600090

Author Information

  1. 1

    Departments of Biomedical Engineering and Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, MA 02215, USA, Fax: (+1) 617-358-3186

  2. 2

    Department of Ophthalmology, Duke University Medical Center, Durham NC 27710, USA

  1. †

    This work was supported by the NIH NEI.

Publication History

  1. Issue published online: 3 AUG 2006
  2. Article first published online: 31 JUL 2006
  3. Manuscript Revised: 4 MAY 2006
  4. Manuscript Received: 7 APR 2006

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Keywords:

  • dendrimers;
  • hydrogels;
  • materials;
  • ophthalmology;
  • polymers
Thumbnail image of graphical abstract

New lysine-based dendrimers which upon reaction with a poly(ethylene glycol) di-activated ester afford a soft flexible hydrogel that can be used to seal a wound in the sclerotomy. These wounds are made during the common ophthalmic procedure of a vitrectomy. The rheological and swelling properties of the hydrogel can be tuned by either changing the concentration, the type, and/or the generation of the dendrimers.

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