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Topical Delivery of Silver Nanoparticles Promotes Wound Healing

  1. Jun Tian Dr.1,
  2. Kenneth K. Y. Wong Dr.1,
  3. Chi-Ming Ho Dr.2,
  4. Chun-Nam Lok Dr.3,
  5. Wing-Yiu Yu Dr.2,
  6. Chi-Ming Che Prof.2,
  7. Jen-Fu Chiu Prof.3,
  8. Paul K. H. Tam Prof.1

Article first published online: 31 OCT 2006

DOI: 10.1002/cmdc.200600171

Issue

ChemMedChem

ChemMedChem

Volume 2, Issue 1, pages 129–136, January 15, 2007

Additional Information

How to Cite

Tian, J., Wong, Kenneth K. Y., Ho, C.-M., Lok, C.-N., Yu, W.-Y., Che, C.-M., Chiu, J.-F. and Tam, Paul K. H. (2007), Topical Delivery of Silver Nanoparticles Promotes Wound Healing. ChemMedChem, 2: 129–136. doi: 10.1002/cmdc.200600171

Author Information

  1. 1

    Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China, Fax: (+852) 2817-3155

  2. 2

    Department of Chemistry, University of Hong Kong, Hong Kong SAR, China

  3. 3

    Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

Publication History

  1. Issue published online: 27 DEC 2006
  2. Article first published online: 31 OCT 2006
  3. Manuscript Received: 22 SEP 2006

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Keywords:

  • cytokines;
  • medicinal chemistry;
  • nanostructures;
  • proteomics;
  • silver;
  • wound healing

Abstract

Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.

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