Superparamagnetic Iron Oxide Nanoparticle–Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

Authors

  • Andrew Z. Wang Dr.,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, 75 FrancisStreet, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
    2. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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    • These authors contributed equally.

  • Vaishali Bagalkot,

    1. Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500712 (South Korea), Fax: (+82) 62-970-2504
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    • These authors contributed equally.

  • Christophoros C. Vasilliou,

    1. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Frank Gu Dr.,

    1. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Frank Alexis Dr.,

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, 75 FrancisStreet, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
    2. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Liangfang Zhang Dr.,

    1. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Mariam Shaikh,

    1. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Kai Yuet,

    1. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Michael J. Cima Prof.,

    1. Department of Material Science and Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Robert Langer Prof.,

    1. Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)
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  • Philip W. Kantoff Prof.,

    1. Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115 (USA)
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  • Neil H. Bander Prof.,

    1. Department of Urology, Weill Medical College of Cornell University, New York, NY 10021 (USA)
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  • Sangyong Jon Prof.,

    1. Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500712 (South Korea), Fax: (+82) 62-970-2504
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  • Omid C. Farokhzad Prof.

    1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, 75 FrancisStreet, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801
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Abstract

original image

Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

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