Communication

Superparamagnetic Iron Oxide Nanoparticle–Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy

  1. Andrew Z. Wang Dr.1,4,†,
  2. Vaishali Bagalkot2,†,
  3. Christophoros C. Vasilliou3,
  4. Frank Gu Dr.4,
  5. Frank Alexis Dr.1,4,
  6. Liangfang Zhang Dr.4,
  7. Mariam Shaikh4,
  8. Kai Yuet4,
  9. Michael J. Cima Prof.5,
  10. Robert Langer Prof.4,
  11. Philip W. Kantoff Prof.6,
  12. Neil H. Bander Prof.7,
  13. Sangyong Jon Prof.2,
  14. Omid C. Farokhzad Prof.1

Article first published online: 9 JUL 2008

DOI: 10.1002/cmdc.200800091

Issue

ChemMedChem

ChemMedChem

Volume 3, Issue 9, pages 1311–1315, September 15, 2008

Additional Information

How to Cite

Wang, Andrew Z., Bagalkot, V., Vasilliou, Christophoros C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, Michael J., Langer, R., Kantoff, Philip W., Bander, Neil H., Jon, S. and Farokhzad, Omid C. (2008), Superparamagnetic Iron Oxide Nanoparticle–Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy. ChemMedChem, 3: 1311–1315. doi: 10.1002/cmdc.200800091

Author Information

  1. 1

    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital and Harvard Medical School, 75 FrancisStreet, Boston, MA 02115 (USA), Fax: (+1) 617-730-2801

  2. 2

    Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500712 (South Korea), Fax: (+82) 62-970-2504

  3. 3

    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)

  4. 4

    Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)

  5. 5

    Department of Material Science and Engineering, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)

  6. 6

    Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115 (USA)

  7. 7

    Department of Urology, Weill Medical College of Cornell University, New York, NY 10021 (USA)

  1. †

    These authors contributed equally.

  1. †

    These authors contributed equally.

Publication History

  1. Issue published online: 5 SEP 2008
  2. Article first published online: 9 JUL 2008
  3. Manuscript Revised: 10 MAY 2008
  4. Manuscript Received: 18 MAR 2008

Funded by

  • National Institutes of Health. Grant Numbers: CA119349, EB003647
  • David H. Koch-Prostate Cancer Foundation Award in Nanotherapeutics
  • Ministry of Health and Welfare. Grant Number: 0720210

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Keywords:

  • doxorubicin;
  • nanoparticles;
  • superparamagnetic;
  • TCL-SPION
Thumbnail image of graphical abstract

Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

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