Communication

HER-2-Targeted Nanoparticle–Affibody Bioconjugates for Cancer Therapy

  1. Frank Alexis Dr.1,2,
  2. Pamela Basto1,2,
  3. Etgar Levy-Nissenbaum Dr.1,2,
  4. Aleksandar F. Radovic-Moreno2,
  5. Liangfang Zhang Dr.2,
  6. Eric Pridgen3,
  7. Andrew Z. Wang Dr.2,4,
  8. Shawn L. Marein1,
  9. Katrina Westerhof1,2,
  10. Linda K. Molnar Dr.5,
  11. Omid C. Farokhzad Prof. Dr.1,2

Article first published online: 14 NOV 2008

DOI: 10.1002/cmdc.200800122

Issue

ChemMedChem

ChemMedChem

Volume 3, Issue 12, pages 1839–1843, December 15, 2008

Additional Information

How to Cite

Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, Aleksandar F., Zhang, L., Pridgen, E., Wang, Andrew Z., Marein, Shawn L., Westerhof, K., Molnar, Linda K. and Farokhzad, Omid C. (2008), HER-2-Targeted Nanoparticle–Affibody Bioconjugates for Cancer Therapy. ChemMedChem, 3: 1839–1843. doi: 10.1002/cmdc.200800122

Author Information

  1. 1

    Department of Anesthesiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St., Boston, MA 02115 (USA), Fax: (+1) 617-730-2801

  2. 2

    Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139 (USA)

  3. 3

    Department of Chemical Engineering, Massachusetts Institute of Technology (USA)

  4. 4

    Department of Radiation Oncology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St., Boston, MA 02115 (USA)

  5. 5

    National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892 (USA)

Publication History

  1. Issue published online: 8 DEC 2008
  2. Article first published online: 14 NOV 2008
  3. Manuscript Revised: 19 SEP 2008
  4. Manuscript Received: 17 APR 2008

Funded by

  • National Institutes of Health

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (489K)

Keywords:

  • targeted therapy;
  • antitumor agents;
  • affibodies;
  • nanoparticles;
  • PLA-PEG copolymers
Thumbnail image of graphical abstract

Affibodies are a class of polypeptide ligand that are potential candidates for tissue-specific targeting of drug-encapsulated controlled release polymeric nanoparticles (NPs). We developed drug delivery vehicles composed of polymeric NPs surface modified with affibody ligands that bind the extracellular domain of the human epidermal growth factor receptor 2 (HER-2) for targeted delivery to cells that overexpress the HER-2 antigen.

View Full Article with Supporting Information (HTML) Get PDF (489K)