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Target-Based Drug Discovery: the Emerging Success of Frontal Affinity Chromatography Coupled to Mass Spectrometry

  1. Enrica Calleri Dr.,
  2. Caterina Temporini Dr.,
  3. Gabriele Caccialanza Prof.,
  4. Gabriella Massolini Prof.

Article first published online: 17 APR 2009

DOI: 10.1002/cmdc.200800436

Issue

ChemMedChem

ChemMedChem

Special Issue: XIX NMMC Verona 2008

Volume 4, Issue 6, pages 905–916, June 8, 2009

Additional Information

How to Cite

Calleri, E., Temporini, C., Caccialanza, G. and Massolini, G. (2009), Target-Based Drug Discovery: the Emerging Success of Frontal Affinity Chromatography Coupled to Mass Spectrometry. ChemMedChem, 4: 905–916. doi: 10.1002/cmdc.200800436

Author Information

  1. Dipartimento di Chimica Farmaceutica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia (Italy), Fax: (+39) 0382-422-975

Publication History

  1. Issue published online: 28 MAY 2009
  2. Article first published online: 17 APR 2009
  3. Manuscript Received: 15 DEC 2008
  4. Manuscript Revised: 12 MAR 2008

Funded by

  • Ministry of Education

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Keywords:

  • drug discovery;
  • high-throughput screening;
  • binding assays;
  • mass spectrometry;
  • FAC–MS

Abstract

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Frontal affinity chromatography coupled to mass spectrometry (FAC–MS) has been reported as a potential method for screening compound mixtures against immobilized target proteins. The potentiality of this analytical approach is described and illustrated with a number of examples based on targets of pharmaceutical interest.

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