SEARCH

SEARCH BY CITATION

Keywords:

  • chemical biology;
  • combinatorial chemistry;
  • drug discovery;
  • melanogenesis;
  • tyrosinase
Thumbnail image of graphical abstract

Small molecules that increase the cellular level of melanin can be used to study melanogenesis, and have therapeutic potential for melanin-related diseases such as albinism. We describe the identification of a potent activator of melanogenesis from a targeted combinatorial library. Treating melanocytes with our most active molecule results in a 1.8-fold increase in melanin levels, and an increase in tyrosinase-catalyzed oxidation of L-tyrosine, a key step in melanin biosynthesis.