Communication

Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif

  1. Jeyanthy Sutharsan1,
  2. Marianna Dakanali Dr.1,
  3. Christina C. Capule1,
  4. Mark A. Haidekker Prof. Dr.2,
  5. Jerry Yang Prof. Dr.1,
  6. Emmanuel A. Theodorakis Prof. Dr.1

Article first published online: 18 DEC 2009

DOI: 10.1002/cmdc.200900440

Issue

ChemMedChem

ChemMedChem

Volume 5, Issue 1, pages 56–60, January 4, 2010

Additional Information

How to Cite

Sutharsan, J., Dakanali, M., Capule, C., Haidekker, M., Yang, J. and Theodorakis, E. (2010), Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif. ChemMedChem, 5: 56–60. doi: 10.1002/cmdc.200900440

Author Information

  1. 1

    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358 (USA), Fax: (+1) 858-822-0386 (ET), Fax: (+1) 858-534-4554 (JY)

  2. 2

    Faculty of Engineering, University of Georgia, Athens, GA 30602 (USA)

Publication History

  1. Issue published online: 23 DEC 2009
  2. Article first published online: 18 DEC 2009
  3. Manuscript Received: 21 OCT 2009

Funded by

  • NSF. Grant Number: CMMI-0652476
  • NIH. Grant Number: 1R21RR025358
  • Wallace H. Coulter Foundation
  • Alzheimer’s Disease Research Center. Grant Number: 3P50 AG005131
  • Alzheimer’s Association. Grant Number: 08-91651

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Keywords:

  • amyloid peptides;
  • fluorescent probes;
  • imaging agents;
  • molecular rotors

Graphical Abstract

Thumbnail image of graphical abstract

New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated β-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions.

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