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Keywords:

  • cytokines;
  • eicosanoids;
  • inflammation;
  • lipoxins;
  • synthesis design
Thumbnail image of graphical abstract

A short and efficient synthesis of new pyridine-containing lipoxin A4 analogues was developed. These analogues induce phagocytosis of apoptotic polymorphonuclear leukocytes and display anti- inflammatory characteristics by suppressing pro-inflammatory cytokine production by macrophages.