Get access

Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A4 Analogues

Authors

  • Colm D. Duffy,

    1. Centre for Synthesis and Chemical Biology, UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland), Fax: (+353) 1-7162501
    Search for more papers by this author
  • Paola Maderna Dr.,

    1. UCD Diabetes Research Centre, Conway Institute of Biomolecular and Biomedical Research, UCD School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4 (Ireland)
    Search for more papers by this author
  • Ciara McCarthy,

    1. School of Biotechnology, Dublin City University, Dublin 9 (Ireland)
    Search for more papers by this author
  • Christine E. Loscher Dr.,

    1. School of Biotechnology, Dublin City University, Dublin 9 (Ireland)
    Search for more papers by this author
  • Catherine Godson Prof.,

    1. UCD Diabetes Research Centre, Conway Institute of Biomolecular and Biomedical Research, UCD School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4 (Ireland)
    Search for more papers by this author
  • Patrick J. Guiry Prof.

    1. Centre for Synthesis and Chemical Biology, UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland), Fax: (+353) 1-7162501
    Search for more papers by this author

Abstract

original image

A short and efficient synthesis of new pyridine-containing lipoxin A4 analogues was developed. These analogues induce phagocytosis of apoptotic polymorphonuclear leukocytes and display anti- inflammatory characteristics by suppressing pro-inflammatory cytokine production by macrophages.

Ancillary