Inside Cover

Inside Cover: North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity (ChemMedChem 8/2009)

  1. Pamela L. Russ1,
  2. Maria J. Gonzalez-Moa Dr.1,4,
  3. B. Christie Vu Dr.2,
  4. Dina M. Sigano Dr.1,
  5. James A. Kelley Dr.1,
  6. Christopher C. Lai Dr.1,
  7. Jeffrey R. Deschamps Dr.3,
  8. Stephen H. Hughes Dr.2,
  9. Victor E. Marquez Dr.1

Article first published online: 30 JUL 2009

DOI: 10.1002/cmdc.200990036

Issue

ChemMedChem

ChemMedChem

Volume 4, Issue 8, page 1210, August 3, 2009

Additional Information

How to Cite

Russ, Pamela L., Gonzalez-Moa, Maria J., Vu, B. Christie., Sigano, Dina M., Kelley, James A., Lai, Christopher C., Deschamps, Jeffrey R., Hughes, Stephen H. and Marquez, Victor E. (2009), Inside Cover: North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity (ChemMedChem 8/2009). ChemMedChem, 4: 1210. doi: 10.1002/cmdc.200990036

Author Information

  1. 1

    Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, 376 Boyles St., Frederick, MD 21702 (USA), Fax: (+1) 301-846-6033

  2. 2

    HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, P.O. Box B, Bldg. 539, Frederick, MD 21702-1201 (USA)

  3. 3

    Naval Research Laboratory, 4555 Overlook Avenue, Code 6030, Washington DC 20375 (USA)

  4. 4

    current address: Arizona State University, 1001 S. McAllister Ave., Code 5901, Tempe, AZ 85287 (USA)

Publication History

  1. Issue published online: 30 JUL 2009
  2. Article first published online: 30 JUL 2009

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Keywords:

  • antiviral agents;
  • carbocycles;
  • conformationally locked;
  • nucleosides;
  • pseudorotational cycles
Thumbnail image of graphical abstract

The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle (nmax=7 °) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening of the embedded cyclopentene ring provides active compounds against HOS cells infected with HIV. For more details, see the Full Paper by V. E. Marquez et al. on p. 1354 ff.

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