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Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)benzenesulfonamide Derivatives and Their Antitumor Mechanisms

  1. Chun-Tang Chiou Dr.1,2,
  2. Grace Shiahuy Chen Prof.1,3,
  3. Meng-Ling Chen1,
  4. Huoming Li4,
  5. Lei Shi5,
  6. Xiang-Hong Huang5,
  7. Wei-Ming Dai Prof.4,5,
  8. Ji-Wang Chern Prof.1,6

Article first published online: 29 JUL 2010

DOI: 10.1002/cmdc.201000228

Issue

ChemMedChem

ChemMedChem

Volume 5, Issue 9, pages 1489–1497, September 3, 2010

Additional Information

How to Cite

Chiou, C.-T., Chen, G. S., Chen, M.-L., Li, H., Shi, L., Huang, X.-H., Dai, W.-M. and Chern, J.-W. (2010), Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)benzenesulfonamide Derivatives and Their Antitumor Mechanisms. ChemMedChem, 5: 1489–1497. doi: 10.1002/cmdc.201000228

Author Information

  1. 1

    School of Pharmacy, National Taiwan University, Taipei 10051 (Taiwan), Fax: (+886) 223939462

  2. 2

    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 11221 (Taiwan)

  3. 3

    Department of Applied Chemistry, Providence University, Shalu 43301 (Taiwan)

  4. 4

    Laboratory of Asymmetric Catalysis and Synthesis Department of Chemistry, Zhejiang University, Hangzhou 310027 (China)

  5. 5

    Center for Cancer Research and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR (China)

  6. 6

    Department of Life Science, National Taiwan University, Taipei 10027 (Taiwan)

Publication History

  1. Issue published online: 30 AUG 2010
  2. Article first published online: 29 JUL 2010
  3. Manuscript Revised: 25 JUN 2010
  4. Manuscript Received: 30 MAY 2010

Funded by

  • National Science Council

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Keywords:

  • antimitotic agents;
  • apoptosis;
  • benzenesulfonamides;
  • cytotoxicity;
  • microtubules
Thumbnail image of graphical abstract

Breaking the cycle: A series of N-(2-arylindol-7-yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone-resistant prostate cancer PC-3 cells, induced G2/M-phase arrest, and induced apoptosis through a caspase-dependent pathway.

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