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Keywords:

  • 18F labeling;
  • cycloadditions;
  • PARP1;
  • PET imaging;
  • tetrazines
Thumbnail image of graphical abstract

Speedy and easy! An 18F-labeled PARP1 imaging agent, based on AZD2281, was prepared via an inverse electron demand Diels–Alder cycloaddition in high radiochemical yield for positron emission tomography (PET) imaging. This strain-promoted ‘bioorthogonal’ reaction is envisioned to be a widely applicable 18F-labeling strategy for repeat and on-demand synthesis of small molecules for PET imaging.