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Keywords:

  • array synthesis;
  • barluenga boronic coupling;
  • C[BOND]C bond formation;
  • drug-likeness
Thumbnail image of graphical abstract

BBC news: C[BOND]C bond formation reactions are underused by medicinal chemists for the preparation of libraries of compounds with good drug-like (“rule-of-five”) and drug fragment-like (“rule-of-three”) properties. Herein we demonstrate the versatility of the Barluenga boronic coupling (BBC) for the preparation of small drug-like and drug fragment-like compounds in parallel.