Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug-like and Drug Fragment-like Molecules



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BBC news: C[BOND]C bond formation reactions are underused by medicinal chemists for the preparation of libraries of compounds with good drug-like (“rule-of-five”) and drug fragment-like (“rule-of-three”) properties. Herein we demonstrate the versatility of the Barluenga boronic coupling (BBC) for the preparation of small drug-like and drug fragment-like compounds in parallel.