These authors contributed equally to this work.
Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug-like and Drug Fragment-like Molecules
Article first published online: 7 NOV 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 7, Issue 2, pages 233–236, February 6, 2012
How to Cite
Nakagawa, S., Bainbridge, K. A., Butcher, K., Ellis, D., Klute, W. and Ryckmans, T. (2012), Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug-like and Drug Fragment-like Molecules. ChemMedChem, 7: 233–236. doi: 10.1002/cmdc.201100339
- Issue published online: 27 JAN 2012
- Article first published online: 7 NOV 2011
- Manuscript Revised: 20 OCT 2011
- Manuscript Received: 12 JUL 2011
- array synthesis;
- barluenga boronic coupling;
- CC bond formation;
BBC news: CC bond formation reactions are underused by medicinal chemists for the preparation of libraries of compounds with good drug-like (“rule-of-five”) and drug fragment-like (“rule-of-three”) properties. Herein we demonstrate the versatility of the Barluenga boronic coupling (BBC) for the preparation of small drug-like and drug fragment-like compounds in parallel.