Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2′′-Ether Analogues

Authors

  • Dr. Janek Szychowski,

    1. Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7 (Canada)
    Search for more papers by this author
  • Dr. Jiro Kondo,

    1. Architecture et Réactivité de l'ARN, IBMC-CNRS, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg Cedex (France)
    2. Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7–1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554 (Japan)
    Search for more papers by this author
  • Omar Zahr,

    1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 2K6 (Canada)
    Search for more papers by this author
  • Prof. Karine Auclair,

    1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 2K6 (Canada)
    Search for more papers by this author
  • Prof. Eric Westhof,

    1. Architecture et Réactivité de l'ARN, IBMC-CNRS, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg Cedex (France)
    Search for more papers by this author
  • Prof. Stephen Hanessian,

    Corresponding author
    1. Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7 (Canada)
    • Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7 (Canada)
    Search for more papers by this author
  • Prof. Jeffrey W. Keillor

    Corresponding author
    1. Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7 (Canada)
    2. Current address: Department of Chemistry, University of Ottawa, 10 Marie-Curie, Ottawa, ON, K1N 6N5 (Canada)
    • Department of Chemistry, Université de Montréal, C. P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7 (Canada)
    Search for more papers by this author

Abstract

original image

Paromomycin analogue activity: Novel amphiphilic aminoglycosides are shown to inhibit clinically relevant deactivating enzymes, without undergoing significant deactivation themselves.

Ancillary