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Keywords:

  • antiviral agents;
  • C34 trimers;
  • fusion inhibitors;
  • gp41;
  • HIV-1
Thumbnail image of graphical abstract

Supramolecular interference: A synthetic peptide mimetic of the trimeric form of gp41 showed significantly increased inhibitory activity against the HIV-1 fusion mechanism. This study demonstrates a useful strategy for the design of effective inhibitors against viral infections that proceed by membrane fusion with host cells.