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Keywords:

  • immunology;
  • isoprenoid biosynthesis;
  • neutrophil extracellular traps;
  • virulence factor;
  • X-ray diffraction
Thumbnail image of graphical abstract

Double whammy! Small molecules that inhibit Staphylococcus aureus dehydrosqualene synthase (CrtM) or host squalene synthase (SQS) are of interest as novel, innate immunity-based therapeutics, blocking virulence or stimulating antibacterial neutrophil extracellular trap (NET) formation. The discovery of leads that do both represents a new route to treating staph infections.