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The Importance of the trans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variants

  1. Wei Ke1,†,
  2. Elizabeth A. Rodkey1,†,
  3. Jared M. Sampson1,
  4. Marion J. Skalweit3,
  5. Anjaneyulu Sheri4,
  6. Dr. Sundar Ram Reddy Pagadala4,
  7. Michael D. Nottingham4,
  8. Prof. John D. Buynak4,
  9. Prof. Robert A. Bonomo2,3,
  10. Prof. Focco van den Akker1,*

Article first published online: 21 MAR 2012

DOI: 10.1002/cmdc.201200006

Issue

ChemMedChem

ChemMedChem

Volume 7, Issue 6, pages 1002–1008, June 2012

Additional Information

How to Cite

Ke, W., Rodkey, E. A., Sampson, J. M., Skalweit, M. J., Sheri, A., Pagadala, S. R. R., Nottingham, M. D., Buynak, J. D., Bonomo, R. A. and van den Akker, F. (2012), The Importance of the trans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variants. ChemMedChem, 7: 1002–1008. doi: 10.1002/cmdc.201200006

Author Information

  1. 1

    Departments of Biochemistry, RT500, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 (USA)

  2. 2

    Departments of Pharmacology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 (USA)

  3. 3

    Research Division, Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106 (USA)

  4. 4

    Department of Chemistry, Southern Methodist University, P.O. Box 750314, 3215 Daniel Ave, Dallas, TX 75275-0314 (USA)

  1. †

    These authors contributed equally to this work.

*Departments of Biochemistry, RT500, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 (USA)

  1. †

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 25 MAY 2012
  2. Article first published online: 21 MAR 2012
  3. Manuscript Received: 4 JAN 2012

Funded by

  • Robert A. Welch Foundation, Houston, USA. Grant Number: N-0871
  • US National Institutes of Health. Grant Numbers: R01 AI062968, R01 AI063517-01
  • US Department of Veterans Affairs, Merit Review Program
  • Cleveland Geriatric Research Education and Clinical Center (GRECC)

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