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Keywords:

  • Alzheimer’s disease;
  • 17β-hydroxysteroid dehydrogenase type 10;
  • hormones;
  • inhibitors;
  • prostate cancer;
  • steroids
Thumbnail image of graphical abstract

Ten out of ten! Androsterone derivatives inhibit 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), a versatile mitochondrial NAD+-dependent enzyme with potential roles in both Alzheimer's disease and prostate cancer. These androsterone derivatives could be useful tool compounds to help elucidate the role of 17β-HSD10 in these important diseases.