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The Development of FtsZ Inhibitors as Potential Antibacterial Agents
Article first published online: 25 MAY 2012
DOI: 10.1002/cmdc.201200156
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Ma, S. and Ma, S. (2012), The Development of FtsZ Inhibitors as Potential Antibacterial Agents. ChemMedChem, 7: 1161–1172. doi: 10.1002/cmdc.201200156
Publication History
- Issue published online: 25 JUN 2012
- Article first published online: 25 MAY 2012
- Manuscript Revised: 5 MAY 2012
- Manuscript Received: 21 MAR 2012
Funded by
- National Natural Science Foundation of China. Grant Numbers: 20872081, 21072114
- Natural Science Foundation of Shandong. Grant Number: ZR2010HM092
- Abstract
- Article
- References
- Cited By
Keywords:
- biological activity;
- FtsZ;
- inhibitors;
- mechanisms of action;
- synthetic methods
Abstract
The emergence and prevalence of bacterial resistance has resulted in a clear demand for novel antibacterial drugs. As a tubulin homologue, FtsZ is an essential cell-division protein in prokaryotic organisms and is showing increasing promise as a target for antibacterial drug discovery. This review describes the role of FtsZ in bacterial cytokinesis and various FtsZ inhibitors, with particular focus on their discovery, antibacterial activities, mechanisms of action, synthetic methods, and representative analogues.