Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

Authors

  • Prof. Dianqing Sun,

    Corresponding author
    1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720 (USA)
    • Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720 (USA)
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    • These authors contributed equally to this work.

  • Prof. Julian G. Hurdle,

    1. Department of Biology, University of Texas at Arlington, Arlington, TX 76019 (USA)
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    • These authors contributed equally to this work.

  • Robin Lee,

    1. Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, TN 38105 (USA)
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  • Prof. Richard Lee,

    1. Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, TN 38105 (USA)
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  • Prof. Mark Cushman,

    1. Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and the Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907 (USA)
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  • Prof. John M. Pezzuto

    1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720 (USA)
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Abstract

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Lead on! In the course of screening flavonoid and resveratrol libraries, abyssinone II, a naturally occurring prenylated flavonoid, was found to exhibit relatively good antitubercular and antibacterial activity. Preliminary mechanistic studies revealed that abyssinone II hyperpolarizes the bacterial membrane potential and inhibits the biosynthesis of key cellular macromolecules (DNA, RNA, and protein).

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