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Keywords:

  • depsides;
  • depsidones;
  • lichens;
  • prostaglandin E2 synthase-1;
  • pharmacophore models
Thumbnail image of graphical abstract

Nature in silico: Virtual screening using validated pharmacophore models identified lichen depsides and depsidones as potential inhibitors of mPGES-1, an emerging target for NSAIDs. Evaluation of the virtual hits in a cell-free assay revealed physodic acid and perlatolic acid as potent inhibitors of mPGES-1 (IC50 = 0.4 and 0.43 μM, respectively), indicating that these natural products have potential as novel anti-inflammatory agents.