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Keywords:

  • cancer;
  • cyclooxygenases;
  • cytotoxicity;
  • N-cyano sulfoximines;
  • inhibitors
Thumbnail image of graphical abstract

From insects to cancer: N-Cyano sulfoximines were evaluated for COX inhibition and antiproliferative activity against a panel of cancer cell lines. The most active compound exhibited potent COX-2 inhibition, some selectivity for COX-2 over COX-1, only slight cytotoxicity towards healthy cells (HaCaT skin cells), and no mutagenic potential (as determined by an Ames assay).