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Keywords:

  • glucagon-like peptide-1 (GLP-1);
  • human pancreatic islets;
  • insulinotropic effects;
  • receptor agonists;
  • vitamin B12
Thumbnail image of graphical abstract

Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of type II diabetes. A new vitamin B12–GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitamin B12 oral uptake pathway for peptide delivery.