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Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Authors

  • Dr. Susan Clardy-James,

    1. Department of Chemistry, Syracuse University, 111 College Place Syracuse, NY 13244 (USA)
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  • Dr. Oleg G. Chepurny,

    1. Department of Medicine, Upstate Medical University, 4310 Institute for Human Performance, Syracuse, NY 13210 (USA)
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  • Dr. Colin A. Leech,

    1. Department of Medicine, Upstate Medical University, 4310 Institute for Human Performance, Syracuse, NY 13210 (USA)
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  • Prof. George G. Holz,

    Corresponding author
    1. Department of Chemistry, Syracuse University, 111 College Place Syracuse, NY 13244 (USA)
    2. Department of Medicine, Upstate Medical University, 4310 Institute for Human Performance, Syracuse, NY 13210 (USA)
    • Department of Chemistry, Syracuse University, 111 College Place Syracuse, NY 13244 (USA)
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  • Prof. Robert P. Doyle

    Corresponding author
    1. Department of Chemistry, Syracuse University, 111 College Place Syracuse, NY 13244 (USA)
    2. Department of Medicine, Upstate Medical University, 4310 Institute for Human Performance, Syracuse, NY 13210 (USA)
    • Department of Chemistry, Syracuse University, 111 College Place Syracuse, NY 13244 (USA)
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Abstract

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Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of type II diabetes. A new vitamin B12–GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitamin B12 oral uptake pathway for peptide delivery.

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