Inside Back Cover: Fluorescein Analogues Inhibit SecA ATPase: The First Sub-micromolar Inhibitor of Bacterial Protein Translocation (ChemMedChem 4/2012)

Authors

  • Ying-Ju Huang,

    1. Department of Biology, Georgia State University, 490 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
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  • Dr. Hongyun Wang,

    1. Department of Biology, Georgia State University, 490 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
    2. Present address: China–Japan Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China)
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  • Prof. Fen-Biao Gao,

    1. Departments of Neurology and Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 (USA)
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  • Prof. Minyong Li,

    1. Department of Chemistry, Georgia State University, 313 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
    2. Present address: Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012 (China)
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  • Dr. Hsiuchin Yang,

    1. Department of Biology, Georgia State University, 490 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
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  • Prof. Binghe Wang,

    Corresponding author
    1. Department of Chemistry, Georgia State University, 313 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
    2. Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303 (USA)
    3. Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303 (USA)
    • Department of Chemistry, Georgia State University, 313 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
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  • Prof. Phang C. Tai

    Corresponding author
    1. Department of Biology, Georgia State University, 490 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
    2. Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303 (USA)
    3. Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303 (USA)
    • Department of Biology, Georgia State University, 490 Petit Science Center, 161 Jesse Hill Jr. Drive, Atlanta, GA 30303 (USA)
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Abstract

original image

The back cover picture shows the inhibition of SecA, a key enzyme in the bacterial general secretion (Sec) pathway. SecA is essential for bacterial growth and as such represents an ideal target for antibacterial agents. The fluorescein derivatives shown represent the first sub-micromolar inhibitors of SecA's ATPase activity. For more details, see the Full Paper by Binghe Wang, Phang C. Tai et al. on p. 571 ff.

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