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Keywords:

  • bicyclic peptides;
  • macrocycles;
  • kallikreins;
  • serine proteases;
  • specificity
Thumbnail image of graphical abstract

The cover picture shows a novel bicyclic peptide inhibitor of the serine protease plasma kallikrein identified by phage display. By modulating the loop size of the peptide macrocycles, inhibitors with sub-nanomolar potency and an optimal specificity profile could be generated. For more details, see the Communication by Greg Winter, John Tite, Christian Heinis et al. on p. 1173 ff.