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Keywords:

  • antibiotics;
  • chirality;
  • drug design;
  • medicinal chemistry;
  • quinolones
Thumbnail image of graphical abstract

The back cover picture shows the structural evolution of fluroqinolone-derived antibacterial agents—particularly the C-7 nitrogen heterocycle, which influences the potency, activity spectrum and safety, from piperazine to pyrrolidine and azetidine. Now, derivatives containing a chiral 3-(alkoxyimino)-2-(aminomethyl)azetidine show promise against Gram-positive strains including methicillin-resistant Staphylococcus aureus (MRSA). For more details, see the Full Paper by Mingliang Liu et al. on p. 1230 ff.