Inside Cover: Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate-Based Inhibitors (ChemMedChem 12/2012)

Authors

  • Loek T. M. van Wandelen,

    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
    2. Netherlands Proteomics Centre, Padualaan 8, 3584 CH, Utrecht (The Netherlands)
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  • Dr. Jeroen van Ameijde,

    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
    2. Netherlands Proteomics Centre, Padualaan 8, 3584 CH, Utrecht (The Netherlands)
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  • Ahmed S. A. Mady,

    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
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  • Angelique E. M. Wammes,

    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
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  • Alois Bode,

    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
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  • Dr. Alex J. Poot,

    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
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  • Dr. Rob Ruijtenbeek,

    1. PamGene International Ltd. Wolvenhoek 10, PO Box 1345, 5200 BJ, Den Bosch (The Netherlands)
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  • Prof. Dr. Rob M. J. Liskamp

    Corresponding author
    1. Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
    • Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht (The Netherlands)
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Abstract

original image

The inside cover picture shows real-time peptide microarrays being used to discover selective peptides that are connected to a set of ATP analogues yielding bisubstrate-based inhibitors displaying tuneable selectivity amongst protein kinase C isozymes. For more details, see the Full Paper by Rob M. J. Liskamp et al. on p. 2113 ff.

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