Back Cover: Two-Photon Fluorescent Imaging of Myelination in the Spinal Cord (ChemMedChem 12/2012)

Authors

  • Allison G. Condie,

    1. Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, Chemistry, and Biomedical Engineering, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 (USA)
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  • Prof. Stanton L. Gerson,

    1. Department of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 (USA)
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  • Prof. Robert H. Miller,

    1. Department of Neuroscience, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 (USA)
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  • Prof. Yanming Wang

    Corresponding author
    1. Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, Chemistry, and Biomedical Engineering, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 (USA)
    • Division of Radiopharmaceutical Science, Case Center for Imaging Research, Department of Radiology, Chemistry, and Biomedical Engineering, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 (USA)
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Abstract

original image

The back cover picture shows 4-((E)-4-((E)-4-aminostyryl)-2,5-dimethoxystyryl)-N-methylaniline, a fluorescent imaging probe, termed CIC, that selectively binds to the myelin sheath that encases axons. In vivo imaging of the spinal cord in mouse models provides insight into multiple sclerosis and other demyelinating human diseases. For more details, see the Full Paper by Yanming Wang et al. on p. 2194 ff.

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