Cover Picture: Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors (ChemMedChem 1/2013)

Authors

  • Pierre Lacotte,

    1. Department of Bioorganic Chemistry and Isotopic Labelling, CEA, Institute of Biology and Technology (iBiTecS), Gif-sur-Yvette 91191 (France), Fax: (+33) 169-087-991
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  • Celine Puente,

    1. Department of Bioorganic Chemistry and Isotopic Labelling, CEA, Institute of Biology and Technology (iBiTecS), Gif-sur-Yvette 91191 (France), Fax: (+33) 169-087-991
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  • Dr. Yves Ambroise

    Corresponding author
    1. Department of Bioorganic Chemistry and Isotopic Labelling, CEA, Institute of Biology and Technology (iBiTecS), Gif-sur-Yvette 91191 (France), Fax: (+33) 169-087-991
    • Department of Bioorganic Chemistry and Isotopic Labelling, CEA, Institute of Biology and Technology (iBiTecS), Gif-sur-Yvette 91191 (France), Fax: (+33) 169-087-991
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Abstract

original image

The front cover picture shows the structure of a new dihydropyrimidin-2-one inhibitor of iodide entrapment in thyroid cells. The identification of this low-nanomolar inhibitor was achieved through an exhaustive structure–activity relationship study in which more than a hundred derivatives in this compound family were designed, synthesized and tested. This discovery opens new perspectives for the development of antithyroid drugs designed to prevent iodide overload in the thyroid gland. For more details, see the Full Paper by Yves Ambroise et al. on p. 104 ff.

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