Inside Cover: From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography (ChemMedChem 1/2013)

Authors

  • Dr. Vani P. Mocharla,

    1. Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230 (USA)
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  • Dr. Joseph C. Walsh,

    1. Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230 (USA)
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  • Dr. Henry C. Padgett,

    1. Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230 (USA)
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  • Dr. Helen Su,

    1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 650 Charles E. Young Dr. South, 23–120 Center for Health Sciences, Los Angeles, CA 90095 (USA)
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  • Dr. Barbara Fueger,

    1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 650 Charles E. Young Dr. South, 23–120 Center for Health Sciences, Los Angeles, CA 90095 (USA)
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  • Prof. Dr. Wolfgang A. Weber,

    1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 650 Charles E. Young Dr. South, 23–120 Center for Health Sciences, Los Angeles, CA 90095 (USA)
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  • Prof. Dr. Johannes Czernin,

    1. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, 650 Charles E. Young Dr. South, 23–120 Center for Health Sciences, Los Angeles, CA 90095 (USA)
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  • Dr. Hartmuth C. Kolb

    Corresponding author
    1. Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230 (USA)
    • Siemens Molecular Imaging Biomarker Research, 6100 Bristol Parkway, Culver City, CA 90230 (USA)
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Abstract

original image

The inside cover picture shows a target-guided approach to identifying positron emission tomography (PET) imaging agents. Incubation of click-chemistry-enabled non-radioactive surrogate fragments with the target enzyme carbonic anhydrase-II generates high-affinity ligands, which can be easily modified into the corresponding radioactive PET tracer without altering its chemical and biological characteristics. For more details, see the Communication by Hartmuth C. Kolb et al. on p. 43 ff.

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