Back Cover: Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold (ChemMedChem 1/2013)

Authors

  • Margaret E. Olson,

    1. Department of Medicinal Chemistry, University of Minnesota – Twin Cities, 717 Delaware Street S.E., Minneapolis, MN 55414 (USA)
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  • Dr. Ming Li,

    1. Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota – Twin Cities, 321 Church Street, Minneapolis, MN 55455 (USA)
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  • Dr. Reuben S. Harris,

    1. Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota – Twin Cities, 321 Church Street, Minneapolis, MN 55455 (USA)
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  • Prof. Dr. Daniel A. Harki

    Corresponding author
    1. Department of Medicinal Chemistry, University of Minnesota – Twin Cities, 717 Delaware Street S.E., Minneapolis, MN 55414 (USA)
    • Department of Medicinal Chemistry, University of Minnesota – Twin Cities, 717 Delaware Street S.E., Minneapolis, MN 55414 (USA)
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Abstract

original image

The back cover picture shows that APOBEC3G (A3G)-mediated cytosine deamination of single-stranded DNA oligonucleotides can be inhibited by 4-amino-1,2,4-triazole-3-thiol-based small molecules. Engagement of A3G C321, which is proximal to the active site, confers activity for this class of compounds. For more details, see the Full Paper by Daniel A. Harki et al. on p. 112 ff.

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