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Keywords:

  • antiviral agents;
  • CCR5;
  • chemokines;
  • HIV-1;
  • R5 isolates;
  • viral replication;
  • vaccine and drug development
Thumbnail image of graphical abstract

Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.