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Keywords:

  • benzimidazoles;
  • cancer;
  • polypharmacology;
  • soluble epoxide hydrolase;
  • stilbenes
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Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.