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From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties

Authors

  • Estel.la Buscató,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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    • These authors contributed equally to this work.

  • Dominik Büttner,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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    • These authors contributed equally to this work.

  • Astrid Brüggerhoff,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Franca-Maria Klingler,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Julia Weber,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Bastian Scholz,

    1. Institut für Pharmazeutische Biologie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Dr. Aleksandra Živković,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Prof. Dr. Rolf Marschalek,

    1. Institut für Pharmazeutische Biologie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Prof. Dr. Holger Stark,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Prof. Dr. Dieter Steinhilber,

    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Prof. Dr. Helge B. Bode,

    1. Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
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  • Prof. Dr. Ewgenij Proschak

    Corresponding author
    1. Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)
    • Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt am Main (Germany)

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Abstract

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Inspired by nature: Natural product isopropylstilbene was identified as an inhibitor of soluble epoxide hydrolase exhibiting antiproliferative properties. Following the natural product inspired design approach, a library of (E)-styryl-1H-benzo[d]imidazoles was synthesized and evaluated with recombinant enzyme and on several cancer cell lines.

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