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Keywords:

  • antiviral agents;
  • carboxamides;
  • hepatitis C;
  • organic synthesis;
  • structure–activity relationships
Thumbnail image of graphical abstract

Fighting HCV: Two potent antiviral analogues were developed from a previously identified lead as novel agents against hepatitis C virus. Their potency and selectivity (5 n: IC50=0.013 μM and EC50=0.018 μM; 5 t: IC50=0.007 μM and EC50=0.024 μM) make them good candidates for further development as antiviral agents.