Design, Synthesis and Biological Evaluation of Trimethine Cyanine Dyes as Fluorescent Probes for the Detection of Tau Fibrils in Alzheimer’s Disease Brain and Olfactory Epithelium

Authors

  • Jiamin Gu,

    1. Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstrasse 22, 64287 Darmstadt (Germany)
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  • Upendra Rao Anumala,

    1. Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstrasse 22, 64287 Darmstadt (Germany)
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  • Dr. Roland Heyny-von Haußen,

    1. Institute of Pathology, Klinikum Darmstadt, Grafenstrasse 9, 64283 Darmstadt (Germany)
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  • Jana Hölzer,

    1. Institute of Diagnostic and Interventional Radiology I, Jena University Hospital-Friedrich Schiller Universität Jena, Erlanger Allee 101, 07747 Jena (Germany)
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  • Valérie Goetschy-Meyer,

    1. F. Hoffmann-La Roche AG, Grenzacherstrasse 124, Gebäude 93/3.44, 4070 Basel (Switzerland)
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  • Dr. Gerhard Mall,

    1. Institute of Pathology, Klinikum Darmstadt, Grafenstrasse 9, 64283 Darmstadt (Germany)
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  • Prof. Dr. Ingrid Hilger,

    1. Institute of Diagnostic and Interventional Radiology I, Jena University Hospital-Friedrich Schiller Universität Jena, Erlanger Allee 101, 07747 Jena (Germany)
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  • Dr. Christian Czech,

    1. F. Hoffmann-La Roche AG, Grenzacherstrasse 124, Gebäude 93/3.44, 4070 Basel (Switzerland)
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  • Prof. Dr. Boris Schmidt

    Corresponding author
    1. Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstrasse 22, 64287 Darmstadt (Germany)
    • Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstrasse 22, 64287 Darmstadt (Germany)

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Abstract

original image

Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post-mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.

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