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Keywords:

  • antiproliferative activity;
  • apoptosis;
  • caspase-3;
  • cell cycle;
  • pyridinium compounds
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Better by benzylthio: A series of 6-substituted 9H-purin-9-yl-pyridinium derivatives was synthesized and evaluated for their antitumor activity. Compounds included in this study elicit variations in cell-cycle progression and an increase of apoptotic cells in a caspase-3-dependent process.