Identification of Chiral Alkenyl- and Alkynylcarbinols as Pharmacophores for Potent Cytotoxicity

Authors

  • Dr. Dounia El Arfaoui,

    1. SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)
    2. LCOA, Faculté des Sciences et Techniques, Université Sidi Mohamed Ben Abdallah, Fès (Marocco)
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  • Dymytrii Listunov,

    1. SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)
    2. Department of Chemistry, Taras Shevchenko National University, Kyiv (Ukraine)
    3. LCC, UPR-CNRS 8241, Université Paul Sabatier-Toulouse III, 205 route de Narbonne, 31077 Toulouse Cedex 4 (France)
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  • Isabelle Fabing,

    1. SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)
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  • Mohamed Oukessou,

    1. SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)
    2. LCOA, Faculté des Sciences et Techniques, Université Sidi Mohamed Ben Abdallah, Fès (Marocco)
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  • Céline Frongia,

    1. ITAV, USR-CNRS 3505, Université Paul Sabatier-Toulouse III, 1 Place Pierre Potier, 31106 Toulouse Cedex 1 (France)
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  • Dr. Valérie Lobjois,

    1. ITAV, USR-CNRS 3505, Université Paul Sabatier-Toulouse III, 1 Place Pierre Potier, 31106 Toulouse Cedex 1 (France)
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  • Arnaud Samson,

    1. ETaC, USR-CNRS 3388, Centre de Recherche et Développement Pierre Fabre, 3 av. Hubert Curien, 31035 Toulouse Cedex 1 (France)
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  • Dr. Frédéric Ausseil,

    1. ETaC, USR-CNRS 3388, Centre de Recherche et Développement Pierre Fabre, 3 av. Hubert Curien, 31035 Toulouse Cedex 1 (France)
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  • Prof. Abdeslem Ben-Tama,

    1. LCOA, Faculté des Sciences et Techniques, Université Sidi Mohamed Ben Abdallah, Fès (Marocco)
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  • Prof. El Mestafa El Hadrami,

    1. LCOA, Faculté des Sciences et Techniques, Université Sidi Mohamed Ben Abdallah, Fès (Marocco)
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  • Prof. Remi Chauvin,

    Corresponding author
    1. LCC, UPR-CNRS 8241, Université Paul Sabatier-Toulouse III, 205 route de Narbonne, 31077 Toulouse Cedex 4 (France)
    • Remi Chauvin, LCC, UPR-CNRS 8241, Université Paul Sabatier-Toulouse III, 205 route de Narbonne, 31077 Toulouse Cedex 4 (France)

      Yves Génisson, SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)

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  • Dr. Yves Génisson

    Corresponding author
    1. SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)
    • Remi Chauvin, LCC, UPR-CNRS 8241, Université Paul Sabatier-Toulouse III, 205 route de Narbonne, 31077 Toulouse Cedex 4 (France)

      Yves Génisson, SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 9 (France)

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Abstract

original image

Illumination by acetylene: Systematic structural variations in a series of archetypal acetylenic lipids derived from the naturally occurring (S,E)-icos-4-en-1-yn-3-ol allowed the discovery of a series of 3R-like 1,4-di-unsaturated carbinol units with a significant and systematic enantiomeric effect on cytotoxicity.

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