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Keywords:

  • autophagy;
  • Atg5;
  • Atg16;
  • molecular modeling;
  • protein–protein interactions
Thumbnail image of graphical abstract

Breaking things down: Disruption of the Atg5–Atg16 protein–protein interaction is a potential strategy for the development of effective inhibitors of autophagy. Using a structural model of the human Atg5–Atg16 complex, a total of 30 Atg16-based peptides were designed and tested for their binding affinity to Atg5. A number of these peptides exhibited binding affinities in the low micromolar range. Furthermore, three Atg16 residues were identified as the key factors in Atg5 binding.