A Template-Based Approach to Inhibitors of Calpain 2, 20S Proteasome, and HIV-1 Protease



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Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P2, and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease.