Inside Cover: Synthesis and Biological Evaluation of Diaryl-Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)-1 Transcriptional Activity (ChemMedChem 2/2013)



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The inside cover picture shows diaromatic-substituted icosahedral carborane, a mimic of manassantin A, which induces hypoxia inducible factor (HIF)-1α protein degradation via the proteasome pathway, leading to inhibition of hypoxia-induced HIF-1 transcriptional activity and suppression of angiogenesis necessary for tumor growth. For more details, see the Full Paper by Hiroyuki Nakamura et al. on p. 265 ff.